Journal of Stem Cell Research & Therapy

Departments of Medicine and Cardiothoracic Surgery, James A. Haley Veterans’ Hospital, University of, USA

Publications

• Opinion Article   
  Acute Myocardial Infarctions and Ischemic Cardiomyopathies both Benefit from Human Umbilical Cord Blood Stem Cells and Chitosan Hydrogels
  Author(s): Robert J Henning*
  
  Regeneration We utilized two separate techniques, human Umbilical Cord Blood Stem Cells (hUCBC) and chitosan hydrogels, to limit acute myocardial infarction size and LV remodeling. Human Umbilical Cord Blood Mononuclear Cells (hUCBC), contain hematopoietic and mesenchymal stem cells. Chitosan is a polysaccharide. Chitosan hydrogels are approved by the United States Food and Drug Administration for human use in drug delivery and are used in repair of skin, nerve, cartilage, and bone. Hydrogels made from chitosan are liquid at room temperature but form a gel matrix at body temperature. We permanently ligated the left anterior descending coronary artery of 100 rats and then randomly divided the rats into control, hUCBC, or chitosan gel treatments. Transthoracic echocardiograms were obtained on rats prior to infarction and then at two, four, and eight weeks after infarction... View more»
  

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