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Reginald M Gorczynski
Department of Immunology, University of Toronto, Toronto Geberal Hospital, Ontario, Canada
Publications
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Review Article
Personalizing Vaccination for Infectious Disease in the 21st Century
Author(s): Reginald M Gorczynski*
Current approaches to vaccination have several underlying assumptions, namely that following immunization most individuals are at similar risk of the disease considered; will react immunologically in the same way (with protective antibodies and/or cell-mediated reactivity) with equivalent and minimal side effects; and that vaccination dosing and frequency of administration does not vary in the population at large. As a result, a widespread delivery of vaccines has been achieved for a number of infectious diseases, with effective control for many of those. It is clear that a weakness of this approach, made manifest with our increasing knowledge of the genomic and proteomic approach to medicine which has come to the fore in the last decade or so, is that it discounts the growing evidence for individual variability in risk; in immune responsiveness; and in response t.. View more»