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Rajneesh Verma
Dr, Paediatric Research Institute, Norway
Publications
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Research Article
Robust, Efficient and Pure Induced Mesenchymal Stem Cells Generation from mRNA Induced Pluripotent Stem Cells in Suspension
Author(s): Rajneesh Verma*, Pornpun Saengmuang, Tanabodee Payuha, Julie D Mendoza, Rotsarin Narang, Naphapatsorn Bondee, Sergei Dmitrievs and Paul Michael Collier
Mesenchymal Stem Cells (MSCs) are involved in many promising clinical trials tackling vastly complicated diseases. Many factors are determining the safety in these clinical trials such as the purity of tissue-derived MSCs cell population used in therapies. Also, the efficacy of the injected MSCs must be tested in-vitro, before application, through proliferation capacity and reproducibility over continuous passages. In addition to, the importance of choosing the right source of MSCs derivation for successful cellular therapy and transplantation. This study demonstrates robust generation of iMSCs from induced Pluripotent Stem Cells (iPSC) of healthy human donor (with full genetic test done prior) using non-integrative (mRNA) method. This conversion method comprises (i) differentiating a population of iPSCs in suspension without iMatrix, (ii) passaging the cells differentiated i.. View more»