Clinical & Medical Biochemistry

Pharmacogenetic Laboratory, Assaf Harofe Medical Center, Beer Yaakov, Israel

Biography

Patricia Benveniste-Levkovitz works in a Pharmacogenetic Laboratory in a Assaf Harofe Medical Center in  Beer Yaakov at Israel Patricia Benveniste-Levkovitz International experience includes various programs, contributions and participation in different countries for diverse fields of study.

Publications

• Research Article   
  Any Polymorphisms of CYP2C9 Affects the Biochemical Profile of Diabetic Patients Receiving Glibenclamide
  Author(s): Shlomit Koren, Ronit Koren, Adina Bar-Chaim, Patricia Benveniste-Levkovitz, Ahuva Golik and Amit Tirosh*
  
  Introduction: Glibenclamide, a hypoglycemic agent, is a member of the sulfonylurea family. It is metabolized by the hepatic P450 CYP2C9. Despite thorough pharmacokinetic characterization of glibenclamide, the evidence for a pharmacogenetic influence on the pharmacodynamics of this medication is scarce. The current study aims to evaluate a possible association between different CYP2C9 alleles and the pharmacodynamic effect of glibenclamide, including hypoglycemic events and required daily glibenclamide dosage. Methods: The patients included were aged ? 18 years, diagnosed with type II diabetes mellitus, and treated with metformin and glibenclamide for at least 3 months. Exclusion criteria were treatment with other hypoglycemic agents or with medications that affect CYP2C9 function. Patients underwent a medical interview, including detailed anti-glycemic treatment dosage and duration. B.. View more»
  

  DOI: 10.35248/2471-2663.1000102

  Abstract PDF