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Ouafaa Fassi Fihri
Department of Biological Science, Hassan II institute of Agronomy and Veterinary, BP 6202-Instituts, 10101, Rabat, Morocco
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Original Research Article
Duration of Immunogenicity of the Recombinant Rift Valley Fever Vaccine MP-12 del-NSm21/384 in Sheep
Author(s): Zahra Bamouh, Zineb Boumart, Meryem Alhyane, Khalid Omari Tadlaoui, George E Bettinger, Douglas M Watts*, Ouafaa Fassi Fihri and Mehdi EL Harrak
Rift Valley Fever Virus (RVFV) is a mosquito-transmitted Bunyavirus capable of causing high morbidity and mortality among humans and domestic ruminants. Vaccination of domestic ruminants with vaccines that provide safe, rapid and long-term protection after a single vaccination is an effective strategy for protecting animals against Rift Valley Fever (RVF) disease. The aim of this study was to determine the duration and titer of antibody elicited by the RVF MP-12 del-NSm21/384 vaccine in sheep. Serum samples were collected from the animals before and after vaccination at various intervals up to one-year post vaccination to determine the duration of the antibody response using a virus-neutralizing test. All vaccinated sheep remained healthy, and RVFV antibody was first detected at two weeks post-vaccination in 37.5% of vaccinated sheep and 100% at three wee.. View more»