Journal of Pain Management & Medicine

Department of Pharmacognosy, College of Medicine Campus, University of Lagos, Lagos, Nigeria

Publications

• Research Article   
  Anti-Arthralgic Activity of the N-Hexane Extract (HTp) of Yellow Oleander Seeds; Thevetia peruviana (Pers.) K. Schum
  Author(s): Odimegwu Joy Ifunanya* and Olabisi Fatiha Oyebola
  
  Thevetia peruviana (Pers.) K. Schum. (Apocynaceae) seeds are known to possess cardio active glycosides such as thevetin A, thevetin B, nerifolin etc. They are also used locally for general pain relief for which there is no scientific evidence to our knowledge. Arthralgia is regarded generally as pain without inflammation. It is endemic in the society and sufferers continue to imbibe pain relieving drugs in their tons all over the world. Analgesic activity test was carried out using the formalin-induced pain models, at 0.1 g, 0.2 g and 0.3 g/kg doses of n-hexane extracts of Thevetia peruviana seeds (HTp) in wistar mice. Diclofenac was used as positive control. Acute toxicity test was carried out at doses of 1000, 2500 and 5000 mg/kg weight of test subject. It was observed that HTp at concentrations of 0.1 g, 0.2 g and 0.3 g/kg showed sig.. View more»
  

  DOI: 10.35248/2684-1320.23.9.230

  Abstract HTML PDF