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Ndukwe PAC
Department of Zoology and Environmental Biology, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria
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Research Article
Hepatoprotective Effect of Methanol Extract of Justicia carnea Leaves on Carbon Tetrachloride-Intoxicated Albino Rats
Author(s): Ukpabi-Ugo JC*, Ndukwe PAC and Iwuoha AG
Introduction: Hepatotoxicity can be caused by drugs overdose (in some cases even when the drugs are administered in therapeutic doses). This may damage the liver temporarily or permanently. The reason for this study is to evaluate the amount of damage caused by carbon tetrachloride (CCl4) on liver and establish a dose-dependent treatment and prevention with Justicia carnea leaves extract. Aim: Hepatoprotective effect of methanol extract of Justicia carnea leaves on carbon tetrachloride intoxicated albino rats was investigated. Methods: A total of thirty-five female wistar albino rats were used for the study and were grouped into 7 groups (I-VII) of 5 rats each. Group I served as normal control which received only feed and water, group II served as CCl4- treated control receiv.. View more»