Advances in Pharmacoepidemiology and Drug Safety

Department of Geosciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil

Publications

• Research Article   
  Estrogen Agonist Induced Effects on Platelet Activation Properties and Platelet Signaling Pathways by Structural Class
  Author(s): Ver�´nica Mendes Soares*, Amanda Mendes da Fonseca, Otávio da Fonseca, Moisés Seabra, Daniela Maria Alves Moreira Ramos, Lorena Thayla Nascimento and Francisco das Chagas Alves Lima
  
  Background: The objective of this study is to identify the electronic structures of Platelet Receptors (RP) and the amino acid residues of the interaction of these receptors with estradiol and isoflavones through molecular anchoring involved in vascular thrombosis, directing investigations into their future clinical applicability. Method: In an online database, G protein-coupled platelet receptors and tyrosine kinases involved in the coagulation process were identified. Bioinformatics tools (molecular anchoring) were used to characterize the interaction between each interaction site and bioactives (estradiol and isoflavones) in pre-clinical studies, evaluating the affinity between ligands and receptors. Results: The molecular anchoring findings indicated that estradiol and isoflavones had good interaction with the .. View more»
  

  Abstract PDF