Journal of Vaccines & Vaccination

Department of Veterinary Surgery and Theriogenology, College of Veterinary and Biomedical sciences, Sokoine University of Agriculture, P.O. Box 3020, Chuo Kikuu, Morogoro, Tanzania

Publications

• Research   
  Evaluation of the Immunogenicity of a Mutagenized Rift Valley Fever MP-12 and a Recombinant Rift Valley Fever arMP12ΔNsm21/384 Vaccine Candidates in Indigenous Species of Cattle, Sheep, and Goats in Tanzania
  Author(s): Salekwa LP, Nyundo SB, Adamson EK, Matiko MK, Bettinger GE, Rowland JM, Palermo PM, Wambura PN, Morrill JC and Watts DM*
  
  Objective: Rift valley fever virus (RVFV) is the cause of devastating outbreaks among domestic ruminants and humans in most African countries and in the Arabian Peninsula. Current efforts to develop and evaluate an improved veterinary vaccine to prevent RVF disease among domestic ruminants includes a live attenuated RVFV MP-12 candidate and a recombinant vaccine referred to as arMP12ΔNsm21/384 that was derived from the RVF MP-12 vaccine candidate. The aim of this study was to evaluate these RVFV vaccine candidates in domestic ruminants in Tanzania. Methods: Six to nine months old goats (Capra aegagrus hircus), calves (Bos taurus indicus) and sheep (Ovis aries) were vaccinated subcutaneously with one ml each of 1 × 105 plaque forming units (PFU)/ml of the RVF MP-12 and/or the arMP-12ΔNSm21/384 candidate vaccines. .. View more»
  

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