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Mariarosaria Valente

Department of Medical Area, DAME, University of Udine, Udine, Italy

  • Review Article   
    Acute Ischemic Stroke Due to Anticoagulation Failure: New Challenging Issues in the DOACs Era
    Author(s): Francesco Janes*, Fedra Kuris, Simone Lorenzut, Gian Luigi Gigli and Mariarosaria Valente

    Primary and secondary prevention of cardio embolic stroke is a key issue in Neurological and Cardiological clinical practice. Anticoagulation proved to be clearly effective, both with Vitamin K Anticoagulants and in the last years with Direct Oral Anticoagulants, in preventing acute ischemic stroke. The proportion of patients prescribed with these drugs is constantly rising in the last decades. However, the occurrence of an anticoagulation failure is responsible for a relevant and increasing proportion of ischemic strokes. In fact, those patients have a different and peculiar risk factors profile, require a more extensive diagnostic work-up to clarify stroke etiopathogenesis and need physicians to pay more attention to drug-to-drug and food-to-drug interactions. Moreover, reperfusion therapies are allowed only under specific conditions. The aim of this paper is to.. View more»

    DOI: 10.35248/ 2329-6925.22.10.451

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