Journal of Vascular Medicine & Surgery

Department of Medicine, The University of Queensland, Brisbane, Australia

Publications

• Research Article   
  Controversies on Dosing of Prophylactic Nimodipine in Subarachnoid Haemorrhage, a Narrative Review
  Author(s): Judith Bellapart*, María Patricia Hernández-Mitre, Charles Yates, Jennifer Paratz and Jason A Roberts
  
  The use of nimodipine for the prophylaxis of neurological complications related to angiographic vasospasm has been a common practice for more than four decades. However, only few trials demonstrated an outcome benefit, defined as a reduction in mortality and vegetative states. By contemporary standards, these benefits may be considered marginal. The controversies regarding the use of nimodipine relate to its mechanism of action, the idiosyncratic factors involved in its effects and the current use of a standardised dose. Furthermore, the multifactorial nature of Delayed Cerebral Ischemia (DCI) adds ambiguity on its clinical endpoints. Consequently, the absence of a specific clinical target limits the capacity to describe a therapeutic plasma level of nimodipine, thus restricting the attainment of individualised dosing. This review aims to consolidate evidence regarding nimodipine dosi.. View more»
  

  Abstract PDF