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Karoina Palcka
Department of Immunology, Baylor Institute for Immunology Research, 3434 Live Oak Street, Dallas, 75204, Texas, United States
Publications
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Opinion Article
Vaccine-Induced Transcriptional Alterations In Human Dendritic Cells
Author(s): Karoina Palcka*
The mechanisms through which microbial vaccines interact with human APCs are still unknown. The transcriptional programmes induced in human DCs by pathogens, innate receptor ligands, and vaccines are described here. We were able to construct a modular framework containing 204 transcript clusters after exposing DCs to influenza, Salmonella enterica, and Staphylococcus aureus. This framework is used to characterise the responses of 13 vaccines to human monocytes, monocyte-derived DCs, and blood DC subsets. Depending on the pathogen, adjuvant formulation, and APC targeted, different vaccines induce distinct transcriptional programmes. Fluzone, Pneumovax, and Gardasil, in turn, activate monocyte-derived DCs, monocytes, and CD1c+ blood DCs, highlighting the importance of APC specialization in vaccine response. Finally, blood signatures from people who have b.. View more»