Journal of Blood Disorders & Transfusion

Associate Clinical Professor of Medicine, Hematology and Oncology Cone Health, Chapel Hill, NC 1200 N Elm St.Greensboro, NC 27401, North Carolina, USA

Publications

• Case Series   
  The Many Faces of Thrombotic Microangiopathies
  Author(s): Granfortuna J*
  
  The thrombotic microangiopathies are a complex group of disorders that typically present with a schistocytic hemolytic anemia and associated thrombocytopenia with ensuing microvascular occlusion leading to tissue ischemia and end organ damage. Central nervous system, renal, gastrointestinal and cardiac microcirculations are frequent targets. Signs and symptoms related to organ dysfunction may evolve over weeks to months and may not be present simultaneously. Lactic dehydrogenase enzyme elevation due to microvascular ischemia is frequently disproportionate to elevation of bilirubin or reticulocyte count. The major thrombotic microangiopathies include Thrombotic thrombocytopenic purpura, Disseminated intravascular coagulation/sepsis, and Hemolytic Uremic Syndrome. Hemolytic Uremic Syndrome may be further divided into “typical”, related to Shiga toxin, &ldqu.. View more»
  

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