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Dwayne R White
Department of Anaesthetics, Harrogate District Hospital, Harrogate, United Kingdom
Publications
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Research
Does Nebulized Unfractionated Heparin Cause Changes in Derived Neutrophil to Lymphocyte Ratios in Severe COVID-19 Pneumonitis?
Author(s): Cecily W Thompson*, Stacey-Ann M Robinson, Jevonne J McIntosh, Jodian S Risden, Dwayne R White, Keri S Morgan and Tamara S Beecher
Background: COVID-19 a multi systemic disorder caused by the SARS-CoV-2 virus with deleterious and often fatal effects on respiratory function. Many therapeutic but expensive options have been presented. Unfractionated heparin is widely available and has been shown to have antiviral properties in vitro (by inhibiting the interaction of the spike protein of the coronavirus with ACE2), as well as anti-inflammatory, mucolytic and anticoagulant effects. Objective: To conduct a retrospective cohort study on COVID-19 patients admitted to an isolation ward in Jamaica to determine if nebulized unfractionated heparin delivered to patients with severe COVID-19 pneumonitis would influence the derived Neutrophil to Lymphocyte Ratio (dNLR), a predictor of infection severity that was routinely measured. Methods: St.. View more»