Journal of Bacteriology & Parasitology

National Institute of Cancerology, Thoracic Oncology Unit, Medical Oncology, Av San Fernando No. 22, Col. Section 16, C.P. 14080, Mexico City, Mexico

Publications

• Research Article   
  Identification and Characterization of a Family of Outer Membrane Proteins of Helicobacter pylori, which Scavenge Iron from Human Sources
  Author(s): Marco Antonio González-López, Cristhian Sánchez-Cruz and José de Jesús Olivares-Trejo*
  
  Introduction: Helicobacter pylori is a gram-negative spiral bacterial, has been associated with peptic ulcers, gastritis, duodenitis, and is believed to be the causative agent of gastric cancer. The sources such as human lactoferrin, haem and haemoglobin can support the H. pylori growth. However, still not fully understood how the process of iron acquisition occurs. An in silico analysis has shown that H. pylori genome has a family of three outer membrane protein regulated by iron (FrpB). Two of them: FrpB1 and FrpB2 were purified as recombinant proteins and their haem- or haemoglobin-binding capability was demonstrated. Unfortunately the last protein of the family (FrpB3) has not been investigated. Methods: In this work FrpB3 was purified by haem-affinity chromatography and its capacity of haem-binding was analyze.. View more»
  

  DOI: 10.35248/2155-9597.19.10.355

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