Journal of Allergy & Therapy

Department of Dermatology, University of Thomas Jefferson, Philadelphia, United States

Biography

Thangavel Chellappagounder is an instructor and also he is in Department of Radiation Oncology, Sidney Kimmel Medical College, Thomas Jefferson University. He has done a total of 46 publications and also 2 projects. he is the assistant professor of Radiation Oncology.

Publications

• Review Article   
  Dark Side of Cancer Therapy: Cancer Treatment Induced Cardiopulmonary Inflammation Fibrosis and Immune Modulation
  Author(s): Chellappagounder Thangavel*
  
  Advancements in cancer therapy increased the cancer free survival rates and reduced the malignant related deaths. Therapeutic options for patients with thoracic cancers include the surgical intervention and combination of chemotherapy with ionizing radiation. Despite these advances, Cancer Therapy-Related Cardiopulmonary Dysfunction (CTRCPD) is one of the most undesirable side effects of cancer therapy. Chemo-radiation therapy or immunotherapy promote acute and chronic cardiopulmonary damage by inducing reactive oxygen species, DNA damage, inflammation, fibrosis, altering cellular immunity, cardiopulmonary failure, and non-malignant related deaths among cancer-free patients. CTRCPD is a complex entity with multiple factors involved in this pathogenesis. Although the mechanisms of cancer therapy induced toxicities are multifactorial, damage to the cardiac and pu.. View more»
  

  Abstract PDF