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Bhanu Prakash Reddy Attunuru
Department of Internal Medicine, AIG Hospitals, Mindspace Rd, Gachibowli, Hyderabad, India
Publications
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Short Communication
Safety and Immunogenicity of Mix-Match of Vaccines- Covishield and Covaxin: A Pilot Study
Author(s): Bhanu Prakash Reddy Attunuru, Podduturi Naveenchander Reddy, Sasikala Mitnala*, Deepika Gujjarlapudi, Sadhana Yelamanchili Veturi and Nageshwar Reddy Duvvur
This single-center prospective observational study was conducted to assess the safety and immunogenicity of combination vaccines AstraZeneca’s ChAdOx1-nCov-19 (Covishield in India) and inactivated whole virion BBV152 (Covaxin). A total of 330 unvaccinated healthy volunteers were screened for SARS-COV-2 seropositivity. RT PCR tests were conducted for seronegative volunteers (n=44). They were randomly assigned to four groups and given either same or mixed vaccines at an interval of 4 weeks between the two doses. Mix and match of vaccines did not evoke any adverse events. Combination of vaccines elicited similar immune responses in 4 groups. They were further studied dividing into homologous and heterologous vaccine groups. In Conclusion, Combination vaccines are safe and immunogenic and heterologous vaccines elicit better immunogenic response. .. View more»