Advances in Pharmacoepidemiology and Drug Safety

Department of Biotechnology and Biochemistry, Oriental Institute of Science and Technology-West Bengal, Vidyasagar University, Midnapore, West Bengal, India

Publications

• Research Article   
  Four Chromosomally Clustered Amph Class-C β-Lactamases Control the Cephalosporin Hydrolysis in Mycobacterium tuberculosis and Similar Genetic Loci Appeared as Pseudogenes in Mycobacterium leprae
  Author(s): Asit Kumar Chakraborty*
  
  Mycobacterium tuberculosis (Mt) chromosomal ten PBPs and one class-A β-lactamase (blaC) were implicated in multidrug resistance against penicillin, cephalosporin and carbapenem drugs. The Mt PonA1 and PonA2 had 34% homologies to E. coli class-A (PBP1A and PBP1B) proteins whereas E. coli class-B PBP2 referred as PbpA and PbpB sub-class proteins with 27% homologies in Mt. The class-C PBPs were, PBP4, MecA_N, DacB1, DacB2 and AmpH1- AmpH4. The PBP3 and PBP5 of E. coli were missing in Mt although PBPB called as PBP3 of Mt whereas AmpH designated sometime as DacA or PBP5. Similarly, AmpH protein wrongly called PBP4 where we could not find any similarity to E. coli PBP4. We investigated the Mt whole genomes (accession nos. AL123456, CP001642, CP054013, CP001641, CP025597) to get authentic PBP4 in Mt strain FDAARGOS_757 genome (protein id. AU.. View more»
  

  DOI: 10.35250/2167-1052.24.13.374

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