Journal of Infectious Diseases and Diagnosis

Department of General and Pediatric Surgery, Tashkent Medical Academy, Tashkent, Uzbekistan

Publications

• Research Article   
  The Role and Place of Nitroxidergic Regulation of The Endothelial System in the Pathogenesis of Acute Lung Abscess
  Author(s): AO Okhunov* and Sh A Bobokulova
  
  Background: Purulent-destructive lung diseases remain a priority among the causes of generalized infection and death. The key to the progression of infection in acute lung abscesses may be associated with impaired barrierfiltration function of this organ, which is based on endothelial dysfunction. Methods: The experiments were carried out on 32 Chinchilla rabbits, in which the model of acute lung abscess was reproduced. Investigated in blood samples at the entrance and exit from the lungs, such indicators as nitrates, nitrites, peroxynitrite, NO-synthase and von Willebrand factor. Conclusion: Nitric oxide produced because of iNOS activation is intended for non-specific protection of the body against a wide range of pathogenic agents, inhibits platelet aggregation and improves local blood circulation. .. View more»
  

  DOI: 10.35248/2576-389X.22.7.187

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