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Akiko Kumagai
Division of Forensic Odontology and Disaster Oral Medicine, Iwate Medical University, Iwate, Japan
Biography
We examined the etiology of hyperkeratosis of the oral mucosa, focusing on antioxidant actions and oxidative stress related to the accumulation of oxidized and damaged molecules.
Publications
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Research Article
Protein Carbonylation as the Pathogenesis of Oral Hyperkeratosis: A Pilot Study
Author(s): Akiko Kumagai* and Koichi Tsunoda
Objective: We examined the etiology of hyperkeratosis of the oral mucosa, focusing on antioxidant actions and oxidative stress related to the accumulation of oxidized and damaged molecules. Materials and Methods: The subjects were non-smoking females with squamous cell hyperplasia, oral lichen planus, epithelial dysplasia, or squamous cell carcinoma. Proteins were extracted from hyperkeratosis tissue specimens. Carbonylated proteins, serving as oxidative stress markers, were detected by western blotting and identified by nano-liquid chromatography-tandem mass spectrometry. In addition, we performed immunohistochemical staining of oral mucosa tissue sections using an anti-hexanoyl-lysine (HEL) antibody. Results: Several carbonylated proteins from hyperkeratosis tissue of the oral mucosa were detected by western blot.. View more»