Journal of Stem Cell Research & Therapy

Zhang Y

Biography

He is currently working in the Boston Children's Hospital in USA.The Zhang lab is interested in how epigenetic modification-mediated dynamic changes in chromatin structure affects gene expression, stem cell reprogramming, germ cell development, beta-cell generation, and drug addiction. In the past decade, the lab has worked on a number of projects that span many aspects of epigenetic modifications that include: 1) ATP-dependent nucleosome-remodeling and deacetylase complex NuRD; 2) various histone methyltransferases, including PRC2 (EZH2) and DOT1L; 3) various histone demethylases such as JmjC family demethylases; 4) histone H2A ubiquitin E3 ligase PRC1; and 5) the Tet family of 5-methylsytosine dioxygenases. Build on the past 15 years of success, the lab has developed and adapted new technologies to meet the new challenges.

Research Interest

• Epigenetic mechanism of cancer drug resistance; • Mechanism of pluripotency and totipotency conversion; mechanism of iPSC generation and SCNT-mediated reprogramming; • CpG island chromatin formation; • Role of Tet and 5mC oxidation products in differentiation and brain function.