Pharmaceutica Analytica Acta

Zakir Sultan

Publications

• Research Article
  The Pharmacokinetic Study of Aspirin, Paracetamol and Naproxen with Magnesium Sulfate
  Author(s): Shah Amran, Sabiha Ferdowsy Koly, Sangita Paul Kundu, Abu Asad Chowdhury, Amjad Hossain, Zakir Sultan, Asma Rahman, Sagar Kumar Paul, Satabdi Shikder, Tasneem Nayla Mredula and Shampa KunduShah Amran, Sabiha Ferdowsy Koly, Sangita Paul Kundu, Abu Asad Chowdhury, Amjad Hossain, Zakir Sultan, Asma Rahman, Sagar Kumar Paul, Satabdi Shikder, Tasneem Nayla Mredula and Shampa Kundu
  
  The present study was designed to evaluate the bioavailability of single drug as well as drug with Mg(II) complexes in the systemic circulation of rats. 132 healthy rats were selected for this study. The rats were fasted for 12 hours (overnight) prior to drug administration and kept fasting up to blood collection after administration of the drugs. The rats were divided in to three groups for each drug of study: control (rats without giving any drugs for each analysis) and group 1 for reference (single drug) and group 2 for test drug i.e. drug-Mg complexes. In this study both the test (drug-Mg complex) drug and corresponding reference drug were administered at the dose of aspirin at 10 mg/kg body weight, paracetamol at 16 mg/kg body weight and naproxen at 16 mg/kg body weight in the solution form through oral route. From the pharmacokinetic study, it was found that concomitant administ.. View More»
  DOI: 10.4172/2153-2435.1000372

  Abstract PDF