Journal of Vascular Medicine & Surgery

Yuichi Tamura

Publications

• Research Article
  Relationship between Digit Ratio and Idiopathic Pulmonary Arterial Hypertension in Japanese Women
  Author(s): Tsunehisa Yamamoto, Yuichi Tamura, Tomohiko Ono, Makoto Takei, Motoaki Sano, Masaharu Kataoka, Hiroyuki Yamagishi, Toru Satoh and Keiichi FukudaTsunehisa Yamamoto, Yuichi Tamura, Tomohiko Ono, Makoto Takei, Motoaki Sano, Masaharu Kataoka, Hiroyuki Yamagishi, Toru Satoh and Keiichi Fukuda
  
  Aim: Endothelin-1 (ET-1) is the key vasoactive mediator in patients with pulmonary arterial hypertension (PAH), and sex steroids are known to influence ET-1 levels. Additionally, the second to fourth digit (2D:4D) ratio is a biometric marker influenced by testosterone concentrations and androgen receptor sensitivity in the uterus, and some reports have linked (2D:4D) ratio to disease predisposition among patients with gender-dependent conditions. Since idiopathic PAH (IPAH) is more prevalent in women, we hypothesized that the 2D:4D ratio could predict a female’s predisposition to developing PAH, reflecting an interaction between ET-1 and sex hormones. Method: This study analyzed 13 female patients with IPAH at Keio University Hospital and 41 unrelated agematched controls. The right hand of patients and controls was photographed using a d.. View More»
  DOI: 10.4172/2329-6925.1000175

  Abstract PDF