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Yue Zhuo
Yue Zhuo
West China Second University Hospital,
Mailing address: No. 20, Section 3, Renmin South Road, Chengdu, Sichuan, 610041
Bolivarian Rep. of Venezuela
Publications
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Research Article
Kif5b Modulates Processing and Secretion of von Willebrand Factor in Endothelial Cells and Mice
Author(s): Yu-Si Luo, Yue Zhuo, Ke Zhang, Xingde Liu, Erhard Hofer and Jian-Dong HuangYu-Si Luo, Yue Zhuo, Ke Zhang, Xingde Liu, Erhard Hofer and Jian-Dong Huang
Von Willebrand factor (VWF) secreted by Weibel-Palade bodies within endothelial cells is critical to maintain normal platelet adhesion during vascular arrest. Because the transportation of VWF is microtubule-dependent partly via kinesin activity, suppression of kinesin could affect intracellular trafficking of VWF. In this study, we investigated the role of Kif5b, the key member of the kinesin superfamily, in the processing and secretion of VWF. A hypothetical interaction between VWF and Kif5b was confirmed and the tail domain of Kif5b was identified as VWF binding region. Knocking-down Kif5b in human umbilical vein endothelial cells led to significantly increased non-stimulated VWF secretion, considerably higher ratio of pro-VWF to mature VWF, and shorter VWF length. Consistent to the in vitro assay, Kif5b knockdown mice demonstrated dramatically increased VWF secretion after epineph.. View More»
DOI: 10.4172/2329-6607.1000249