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Yazan Ranneh
Yazan Ranneh
Malaysia
Publications
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Research Article
Influence of Demethylation Pathway on the Differentiation Potential of Human Mesenchymal Stem Cells
Author(s): Faisal Ali, Yazan Ranneh, Amin Ismail and Bart vaesFaisal Ali, Yazan Ranneh, Amin Ismail and Bart vaes
Osteoporosis is associated with a decrease in the commitment of Mesenchymal stem cells (MSC) to the bone forming osteoblast lineage and an increase in the commitment to the fat forming adipocyte lineage in bone marrow of elderly persons. A link between methylation pathway and MSC differentiation remains unclear. Therefore, we hypothesize that alterations in the commitment and differentiation potential of MSC during osteoporosis may be mediated by modification of global methylation pathway. To examine the role of methylation pathway on the differentiation potential of MSC into osteoblasts or adipocytes, human MSC, were used. Adox, which mimics hyperhomocysteinemia effect, was added to cells as a potent methylation inhibitor to block the global methylation pathway of DNA, RNA, Lipid and protein. The effect of demethylation on osteoblast differentiation was determined by.. View More»
DOI: 10.4172/2157-7633.1000153