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Yang Ke
Yang Ke
Bolivarian Rep. of Venezuela
Publications
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Research Article
Protective Effects of Cerebrospinal Fluid With the Intake of Xixin Decoction on Hippocampal Neuron Apoptosis Induced by Aβ1-42
Author(s): Diwu Yong-chang, Meng Ting-ting, Wang Fang, Gu Zan, Zeng Jian, Yang Ke, Cui Na and Gu Jie Diwu Yong-chang, Meng Ting-ting, Wang Fang, Gu Zan, Zeng Jian, Yang Ke, Cui Na and Gu Jie
Objective: To study the protective effects of cerebrospinal fluid with the intake of Xixin Decoction (CSF) on Aß1-42-induced apoptosis in rat hippocampal neurons. Methods: Hippocampal neurons were extracted from Wistar newborn rats and cultured in vitro. Cultured neurons were divided into the following groups: the normal control group, the Aß model group, the low concentration treatment group, the medium concentration treatment group, and the high concentration treatment group. We analyzed cell viability using an MTT assay. Cell apoptosis was observed using transmission electron microscopy, and the rate of cell apoptosis was measured with flow cytometry using Annexin V/PI double staining kit. The gene expression and protein expression levels of Caspase-9, Bcl-2, and Bax in cells were measured using Real-time PCR, Western blot, an.. View More»
DOI: 10.4172/2329-8847.1000175