Journal of Stem Cell Research & Therapy

Xiongbing Lu

Biography

He is currently working as an Associate Professor in the  Department of Cancer Biology at  University of Texas MD Anderson Cancer Center, Houston, TX.He is also Member of the Graduate Faculty, The University of Texas Graduate School of Biomedical Sciences, Houston, TX.He completed graduation in Shanghai Institute of Biochemistry, Chinese Academy of Sciences, Shanghai, China, PHD, Biochemistry.e completed Postdoctoral Fellow, Cancer Biology, Baylor College of Medicine, Houston, TX.

Research Interest

Genomic DNA of human cells is under the constant attack of chemicals, free radicals, and UV or ionizing radiation from environmental exposure, by-products of intracellular metabolism, or medical therapy. In response to diverse genotoxic stresses, cells activate DNA damage checkpoint pathways to protect genomic integrity and promote survival of the organism. DNA damage response are a cascade of phosphorylation events initiated by the activation of phosphoinositide 3-kinase (PI3K)-related protein kinases including ATM, ATR and DNA-PK. A vast network of over 700 ATM/ATR targets have been identified and shown to play pivotal roles in the complex cellular response to DNA damage.