Journal of Stem Cell Research & Therapy

Wen-Bo Wang

Publications

• Research Article
  CD133 and MYCN Amplification Induce Chemo-Resistance and Reduce Average Survival Time in Pediatric Neuroblastoma
  Author(s): Zhi-Yong Zhong, Bao-Jun Shi, Hui Zhou and Wen-Bo WangZhi-Yong Zhong, Bao-Jun Shi, Hui Zhou and Wen-Bo Wang
  
  Objectives: Neuroblastoma (NB) is the most common pediatric solid tumor derived from the sympathetic nervous system. MYCN gene exists in nearly half of the NB patient and its association with rapid disease progression and poor outcome is controversial. Cancer Stem Cells (CSCs) characterization in NB has been rarely studied. This study is to figure out whether the MYCN gene and CSCs are associated with chemotherapy resistance and survival time in the NB patients. Methods: Based on unequivocal pathological diagnosis, 50 NB patients are recruited. MYSN amplification is measured before any therapy. The CSCs are derived and their multi-potencies are tested by directed differentiation. Response to chemotherapy and average survival time of these patients are gathered and compared with following groups: CD133+, CD133-, MYCN ≥ 5, MYCN<5, CD133+.. View More»
  DOI: 10.4172/2157-7633.1000394

  Abstract PDF