Journal of Vascular Medicine & Surgery

Weber MA

Publications

• Research Article
  Dynamic Quantitative Contrast-enhanced Ultrasound for Assessment of Cilostazol Induced Pro-angiogenic Therapeutic Effects on Skeletal Muscle Microcirculation in Peripheral Arterial Disease
  Author(s): Kauczor HU, Amarteifio E, Partovi S, Weber MA, Macys L, Delorme S, Krix M, Böckler D and Demirel SKauczor HU, Amarteifio E, Partovi S, Weber MA, Macys L, Delorme S, Krix M, Böckler D and Demirel S
  
  Purpose: To assess the effect of cilostazol on muscular microperfusion in patients with peripheral artery occlusive disease (PAOD) using dynamic quantitative contrast-enhanced ultrasound (CEUS). Materials and Methods: 20 patients with PAOD, Rutherford classification grade I, category III were evaluated performing CEUS with the arterial occlusion paradigm, ankle-brachial-index (ABI) and treadmill walking distance test before and after oral treatment with cilostazol for three months. Microperfusion of the calf skeletal muscle was assessed using quantitative CEUS parameters which were extracted from time signal-intensity curves (TIC). Results: 10 patients had to be taken off medication secondary to side effects. Maximum CEUS signal enhancement prior to therapy was 104 ± 69 ~mL compared to 114±68 ~mL post treatment (P=0.26). tmax was 34 ± 20 s before and 36 ± 2.. View More»
  DOI: 10.4172/2329-6925.1000284

  Abstract PDF