Journal of Bacteriology & Parasitology

Varela JN

Publications

• Research Article
  Effects of Salmonella enteritidis serovar typhimurium Infection in Adenocarcinomic Human Alveolar Basal Epithelial Cells A549 In vitro: Bacteria Induce Apoptosis in Adenocarcinomic Cell
  Author(s): Izidoro MS Jr, Varela JN, Alves DA, Pereira RFC, Brocchi M, Lancellotti M and Hollanda LMIzidoro MS Jr, Varela JN, Alves DA, Pereira RFC, Brocchi M, Lancellotti M and Hollanda LM
  
  Salmonella enterica serovar typhimurium is a facultative anaerobic bacterium, gram-negative, flagellated which generally develops and grows preferably in a wide variety of tumor cells. Until now, several factors for this predilection have been described, such as: an increase in number of nutrients favorable for bacterial growth due to rapid growth of the tumor cells, adaptation of S. typhimurium, loss of macrophages and neutrophils bactericidal activity in areas of hypoxia, the absence of antibodies and complement factors around the tumor. This study analyzed the infection in vitro of Salmonella enteritidis serovar typhimurium in A549 cell lineage, in three different aspects: morphological characterization of the infection, analysis of cellular DNA degradation and production of cytokines such as TNFα. The morphological assay showed tumor cell shrinkage, nuclear fragmentation wit.. View More»
  DOI: 10.4172/2155-9597.1000158

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