Journal of Blood Disorders & Transfusion

Uhlin Michael

Publications

• Review Article
  7Mixed Chimerism after Allogeneic Stem Cell Transplantation - Focus on Double Cord Blood Transplantation
  Author(s): Gertow Jens, Stikvoort Arwen, Watz Emma, Mattsson Jonas and Uhlin MichaelGertow Jens, Stikvoort Arwen, Watz Emma, Mattsson Jonas and Uhlin Michael
  
  Allogeneic hematopoietic Stem Cell Transplantation (ASCT) is well established as a curative treatment for many hematological malignancies and non-malignant disorders. The aim of ASCT in these diseases is to achieve sustained donor engraftment to fight leukemic cells in malignant disease, improve hematopoietic function, provide immune competence or normalize enzyme deficiency. Peripheral blood or bone marrow is commonly used to monitor engraftment after ASCT. The presence of mixed donor/recipient chimerism after transplantation, donor/donor chimerism after double cord blood transplantation can be used and interpreted differently based on the initial disease status. In patients with malignant diseases, chimerism is primarily used to detect early relapse but can also indicate threatening rejection. In individuals with non malignant disease, chimerism is merely used to monitor successful .. View More»
  DOI: 10.4172/2155-9864.S1-006

  Abstract PDF