Journal of Vascular Medicine & Surgery

Taro Mizutani

Publications

• Research Article
  Concomitant Down-Regulation of Et1-Etb System and VEGF Angiogenic Signaling in the Frontal Cortex of Endotoximic Mice: A Heightened Vulnerability to Cerebral Microcirculation in Sepsis
  Author(s): Aiko Sonobe, Subrina Jesmin, Nobutake Shimojo, Majedul Islam, Tanzila Khatun, Masami Oki, Satoru Kawano and Taro MizutaniAiko Sonobe, Subrina Jesmin, Nobutake Shimojo, Majedul Islam, Tanzila Khatun, Masami Oki, Satoru Kawano and Taro Mizutani
  
  Aims: Sepsis is a disease that involves abnormal alterations in the microcirculation, with endothelial dysfunction playing a central role in the pathogenesis and mortality. The exact pathophysiology of brain dysfunction associated with sepsis remains poorly understood and experimental data are scarce. It is likely that cerebral microcirculatory alterations may play a potential role. Thus, the present study sought to investigate whether key angiogenic pathways are altered in the frontal cortexin a clinically-relevant animal model of endotoxemia/sepsis, and verify whether the alterations in angiogenic pathways affect the cerebral capillary density. Main methods: Male mice at 8 weeks of age were administered either with saline alone (control group) or 20 mg/kg lipopolysaccharide (LPS) (treatment group) at different time points (1, 3, 6, and 10 h).. View More»
  DOI: 10.4172/2329-6925.1000206

  Abstract PDF