Journal of Vascular Medicine & Surgery

Taro Mizutani

Publications

• Research Article
  Landiolol Hydrochloride Ameliorates Liver Injury in a Rat Sepsis Model by Down Regulating Hepatic TNF-A
  Author(s): Yasuyo Yoshino, Subrina Jesmin, Majedul Islam, Nobutake Shimojo, Hideaki Sakuramoto, Masami Oki, Tanzila Khatun, Masato Suda, Satoru Kawano and Taro MizutaniYasuyo Yoshino, Subrina Jesmin, Majedul Islam, Nobutake Shimojo, Hideaki Sakuramoto, Masami Oki, Tanzila Khatun, Masato Suda, Satoru Kawano and Taro Mizutani
  
  Aims: The effects of a beta blocker, especially an ultra-short acting selective beta blocker, such as landiolol hydrochloride on the organ protection in sepsis are unclear. The present study aimed to investigate whether acute (early hours) liver injury in a rat model of sepsis induced by lipopolysaccharide (LPS) administration: a) can be corrected by administering landiolol and b) whether landiolol’s effects on liver injury is accomplished by diminishing the elevated expression of inflammatory cytokine, such as tumor necrosis factor (TNF)-α and a vaso constrictor peptide, such as endothelin (ET)-1. Methods: Eight (8)-week-old male Wistar rats were administered for three hours with either LPS (n=12), or continuously with LPS plus landiolol (n=11). Control rats were treated with saline only in a similar manner as the treatment group .. View More»
  DOI: 10.4172/2329-6925.1000194

  Abstract PDF