Journal of Carcinogenesis & Mutagenesis

Sunirmal Paul

Publications

• Research Article
  Differential Effect of Active Smoking on Gene Expression in Male and Female Smokers
  Author(s): Sunirmal Paul and Sally A AmundsonSunirmal Paul and Sally A Amundson
  
  Smoking is the second leading cause of preventable death in the United States. Cohort epidemiological studies have demonstrated that women are more vulnerable to cigarette-smoking induced diseases than their male counterparts, however, the molecular basis of these differences has remained unknown. In this study, we explored if there were differences in the. patterns between male and female smokers, and how these patterns might reflect different sex-specific responses to the stress of smoking. Using whole genome microarray gene expression profiling, we found that a substantial number of oxidant related genes were expressed in both male and female smokers, however, smoking-responsive genes did indeed differ greatly between male and female smokers. Gene set enrichment analysis (GSEA) against reference oncogenic signature gene sets identified a large number of oncogenic pathway gene-sets .. View More»
  DOI: 10.4172/2157-2518.1000198

  Abstract PDF