PMC/PubMed Indexed Articles
Indexed In
- Open J Gate
- Academic Keys
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- Publons
- Euro Pub
- Google Scholar
Useful Links
Share This Page
Journal Flyer
Open Access Journals
- Agri and Aquaculture
- Biochemistry
- Bioinformatics & Systems Biology
- Business & Management
- Chemistry
- Clinical Sciences
- Engineering
- Food & Nutrition
- General Science
- Genetics & Molecular Biology
- Immunology & Microbiology
- Medical Sciences
- Neuroscience & Psychology
- Nursing & Health Care
- Pharmaceutical Sciences
Subehan
Subehan
Indonesia
Publications
-
Research Article
Effect of an Isolated Active Compound (BVI03) of Boehmeria virgata (Forst) Guill leaves on Anti-Proliferation in Human Cancer Cervix HeLa Cells through Activation of Caspase 3 and p53 Protein
Author(s): Marianti Manggau, Lukman, Muhammad Rusdi, Mochammad Hatta, Wardihan A Sinrang and SubehanMarianti Manggau, Lukman, Muhammad Rusdi, Mochammad Hatta, Wardihan A Sinrang and Subehan
In this study, we found that BVI03 an alkaloid compound isolated from B. virgate induced antiproliferation against the human cervix carcinoma cell line HeLa. A MTT assay indicated that BVI03 had a strong tumor inhibition (IC50=0.126 μg/mL), which was superior to that of tamoxifen (IC50=2.879 μg/mL). This study also investigated the mechanism of antiproliferation induced by BVI03. Enzymatic activity using a colorimetric assay kit was performed to determine work mechanism of BVI03. Our data indicate that p53 and caspase-3 are involved in the process of BVI03-induced antiproliferative in HeLa cell compare with untreated HeLa cells. .. View More»
DOI: 10.4172/2329-9088.1000125