Journal of Nanomedicine & Nanotechnology

Suárez BN

Publications

• Research Article
  Smart Release Nano-formulation of Cytochrome C and Hyaluronic Acid Induces Apoptosis in Cancer Cells
  Author(s): Figueroa CM, Suárez BN, Molina AM, Fernández JC, Torres Z and Kai GriebenowFigueroa CM, Suárez BN, Molina AM, Fernández JC, Torres Z and Kai Griebenow
  
  Herein we tested a nanosized cancer-cell targeted delivery system based on cytochrome c (Cyt c) and hyaluronic acid. Cyt c was chosen since it is a per se non-toxic protein but causes apoptosis when delivered to the cytoplasm of target cells. Hyaluronic acid was employed to create the nanosized delivery system with passive targeting capability in order to exploit the enhanced permeation and retention (EPR) effect and active targeting capability of hyaluronic acid. In addition, our goal was to incorporate a smart release strategy to only promote protein release upon reaching its target. Nanoparticles were formed by a simple yet precise nanoprecipitation process based on desolvation. They were physically characterized to select precipitation conditions leading to adequate size, shape, protein bioactivity, and protein loading to produce a feasible targeted cancer treatment. We synthesize.. View More»
  DOI: 10.4172/2157-7439.1000427

  Abstract PDF