Journal of Vascular Medicine & Surgery

Stefan Borgwardt

Publications

• Research Article
  Akt2 Gene is Associated with Anxiety and Neuroticism in Humans
  Author(s): Lucia Engeli, Marcel Delahaye, Stefan Borgwardt, Jurgen Gallinat, Daniel Muller, Marc Walter, Undine E Lang and Johannes BeckLucia Engeli, Marcel Delahaye, Stefan Borgwardt, Jurgen Gallinat, Daniel Muller, Marc Walter, Undine E Lang and Johannes Beck
  
  Background: The exact cellular and molecular mechanisms underlying the pathophysiology, successful treatment and prevention of the highly associated anxiety and depressive disorders have not been identified. Akt2 is a key protein in the Phosphatidylinositide-3 (PI3K)/ Glycogen Synthase 3 kinase (GSK3) signaling pathway. This pathway is involved in Brain-Derived Neurotropic Factor (BDNF) signaling, fear memory, mood stabilization and action of several antidepressant drugs. In this study, we examined whether Akt2 Single Nuclear Polymorphisms (SNP) are associated with anxiety and depression associated personality traits. Methods: Four hundred and sixty-three healthy participants completed a self-rating scale for anxiety traits (Spielberger Trait-Anxiety Inventory, STAI) and depressive personality traits (NEO-FFI). Four SNPs of the Akt2 gene (rs72.. View More»
  DOI: 10.4172/2329-6925.1000141

  Abstract PDF