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Stanley Mukanganyama
Stanley Mukanganyama
Biomolecular Interactions Analyses Group, Department of Biochemistry, University of Zimbabwe, P.O. Box MP 167, Mt. Pleasant, Harare,
Zimbabwe
Publications
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Research Article
Inhibitory Activity of Combretum zeyheri and its S9 Metabolites against Escherichia coli, Bacillus subtilis and Candida albicans
Author(s): Charlotte Masengu, Faith Zimba, Rumbidzai Mangoyi and Stanley MukanganyamaCharlotte Masengu, Faith Zimba, Rumbidzai Mangoyi and Stanley Mukanganyama
Medicinal plants are therapeutic resources used by traditional population for health care, thus, it is important to evaluate the mechanism of action of herbal plants so as to validate their efficacy and avoid possible toxic effects. The water and methanol leaf extracts of Combretum zeyheri, medicinal plant from Zimbabwe were screened for antibacterial activity against Escherichia Coli and Bacillus subtilis using the agar disc diffusion method. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of the plant extracts were determined using the broth dilution method. Drug transport assays were conducted to test the potential of plant extracts as inhibitors of drug efflux using in Rhodamine 6G. The effect of Combretum zeyheri plant S9 metabolites on growth of Candida albicans was investigated using S9 fractions from 8 week old male Sprague-Dawley rat.. View More»
DOI: 10.4172/1948-5948.1000149