Journal of Bioequivalence & Bioavailability

Shoichi Shirotake

Publications

• Research Article
  Screening Bactericidal Action of Cytoplasm Extract from Kumazasa Bamboo (Sasa veitchii) Leaf against Antibiotics- Resistant Pathogens such as MRSA and VRE Strains
  Author(s): Shoichi Shirotake, Jutaro Nakamura, Akiko Kaneko, Eri Anabuki and Naoto ShimizuShoichi Shirotake, Jutaro Nakamura, Akiko Kaneko, Eri Anabuki and Naoto Shimizu
  
  We aimed to develop a new treatment against antibi- otic-resistant bacteria by focusing on cytoplasm of Kumazasa bamboo leaf. The cytoplasmic extract displ ays potent bactericidal action against Gram-positive ba cte- ria such as Staphylococcus aureus, Enterococci and Strep- tococcus pneumoniae and also multi-antibiotic resis tant MRSA (methicillin-resistant Staphylococcus aureus) and VRE (vancomycin-resistant Enterococci) strains. It in- duced bacteriolysis by firmly aggregating MSSA (me- thicillin-susceptible Staphylococcus aureus) and MR SA, and by lysis of VSE (vancomycin-susceptible Entero- cocci) and VRE. Clinical isolates of MRSA (30 strai ns in total) were susceptible to this extract, which g ave MICs of Kumazasa-cytoplasmic extract ranging from 1.6 to 6.3%. The antibacterial action was bactericidal on scan- ning electron microscopy (SEM) analysis. A synergis tic effect of this.. View More»
  DOI: 10.4172/jbb.1000012

  Abstract PDF