Journal of Pharmacovigilance

Sérgio Luiz Prior

Publications

• Research Article
  Metabolic Alterations Associated With Antipsychotic Use–A Descriptive Study and Comparison between Haloperidol and Olanzapine in Schizophrenic and Bipolar Patients
  Author(s): Sérgio Luiz Prior, Antonio Ricardo de Toledo Gagliardi, Marcos Montani Caseiro and Pedro Luis PriorSérgio Luiz Prior, Antonio Ricardo de Toledo Gagliardi, Marcos Montani Caseiro and Pedro Luis Prior
  
  Introduction: Antipsychotic drugs are essential to psychiatric health in many conditions, such as schizophrenia and bipolar disorder. However, they present several side effects, such as motor dystonia and “Parkinson-like” behavior (especially in first generation antipsychotics) and metabolic alterations leading to increased body weight, type 2 diabetes and dyslipidemias. Second generation antipsychotics are widely regarded as more damaging in metabolic side effects, though there are few studies comparing if first generation antipsychotics can provoke similar changes in metabolism. Methods: An observational-transversal-descriptive study was conducted in a total of 63 patients in use of their first generation (haloperidol–N=27) or second generation antipsychotic–olanzapine–N=36). Blood samples were collected to assess the f.. View More»
  DOI: 10.4172/2329-6887.1000143

  Abstract PDF