Sathish Kumar M

Sathish Kumar M
CSIR OSDD Research Unit,
Bangalore
India

Publications
  • Research Article
    Molecular Docking Studies of PA-824 with Pyridoxine 5'-Phosphate Oxidase
    Author(s): Sathish Kumar M and Jaleel UCASathish Kumar M and Jaleel UCA

    Mycobacterium tuberculosis is to be one of the world’s most deadly pathogens. The PA-824 nitroimidazole is a prodrug with an action activity against both hypoxic and replicating of Mycobacterium tuberculosis. PA-824 molecule was activated by a cofactor, which is a compound that binds to a protein. This prodrug was used as a ligand to bind with the protein PDB ID: 1XXO (Pyridoxine 5'-phosphate oxidase complexed with pyridoxal 5'-phosphate). Pyridoxine 5-phosphate oxidase is called as the enzyme that catalyzes the B6 metabolism pathway by limits the rate step process. Docking analysis was performed on the protein 1XX0 along with ligand PA-824 using Autodock. .. View More»
    DOI: 10.4172/0974-8369.1000274

    Abstract PDF