Journal of Bioequivalence & Bioavailability

Saeedur Rasheed Nazir

Publications

• Research Article
  Designing, Development and Formulation of Mouth Disintegrating Telmisartan Tablet with Extended Release Profile Using Response Surface Methodology
  Author(s): Muhammad Abdullah Akram, Taha Nazir, Nida Taha, Adeel Adil, Muhammad Sarfraz and Saeedur Rasheed NazirMuhammad Abdullah Akram, Taha Nazir, Nida Taha, Adeel Adil, Muhammad Sarfraz and Saeedur Rasheed Nazir
  
  The Mouth Disintegrating Tablets (MDT’s) is continuously growing in clinical practice. The pharmaceuticals researchers are exploring the formulations for extended release dosage form with optimal therapeutic benefits. Hence, we aimed this study to develop the mouth disintegrating telmisartan tablet with extended release profile using response surface methodology. Mouth Disintegrating Extended Release Tablets (MDERT’s) was prepared with the intention of obtaining immediate as well as sustain therapeutic effect. The MDERT’s characterized with different determinants. The results were tabulated to illustrate the drug release curves of all 6 formulations upto 12 hrs, DSC spectra of Telmisartan, Kyron T134134, Primogel, Telmisartan + Kyron T134134 + Primogel, Chitosan, CMC and different excepients. The response surface models were developed for disintegration time, wetting.. View More»
  DOI: 10.4172/jbb.1000250

  Abstract PDF