Journal of Pharmacovigilance

Robert Kowalski

Publications

• Review Article
  Thiopurine S-Methyltransferase Phenotype and Genotype in Pediatric Patients with Inflammatory Bowel Disease; Implication for Azathioprine Treatment
  Author(s): Maciej Jankowski, Piotr Landowski, Robert Kowalski, Ewelina Kreft, Irena Audzeyenka, Malgorzata Kasztan, Barbara Kaminska and Miroslawa Szczepanska-KonkelMaciej Jankowski, Piotr Landowski, Robert Kowalski, Ewelina Kreft, Irena Audzeyenka, Malgorzata Kasztan, Barbara Kaminska and Miroslawa Szczepanska-Konkel
  
  Inflammatory Bowel Disease (IBD) is more prevalent in children than adults, and the incidence is increasing. IBD is treated with thiopurines, metabolized by thiopurine S-methyltransferase (TPMT) and inter-individual variability in activity of TPMT affecting therapy efficiency and drug toxicity arises from genetic polymorphisms, mainly TPMT*2, *3A, and *3C. The aim was to investigate the frequency distribution of TPMT activity, determine the penetration rate of TPMT*2, *3A, and *3C alleles in children, and compare TPMT activity in children and adults with IBD. The study included 85 children, 45% with Crohn’s disease (CD) and 55% with ulcerative colitis (UC), and 31 adults with IBD. TPMT activity was measured with radiochemistry. TPMT*2, *3A, and *3C alleles were investigated with PCR and restr.. View More»
  DOI: 10.4172/2329-6887.1000113

  Abstract PDF