Journal of Stem Cell Research & Therapy

Remy Gressin

Publications

• Review Article
  Extracorporeal Photopheresis: Scientific and Technical Considerations for Improving Clinical Management of Patients
  Author(s): Frédéric Garban, Caroline Makowski, Sylvain Carras, Philippe Drillat, Remy Gressin, Jean Yves Cahn and David LaurinFrédéric Garban, Caroline Makowski, Sylvain Carras, Philippe Drillat, Remy Gressin, Jean Yves Cahn and David Laurin
  
  Extracorporeal photopheresis or chemophototherapy (ECP) is a current therapy and concept that has demonstrated clinical efficacy in the treatment of acute and chronic graft versus host disease (GVHD), Sezary syndrome or cutaneous T-cell lymphoma (CTCL) and organ transplant rejection. Patient inclusion in ECP protocols increases due to the diffusion of technical progress but has to be explored regarding various schedules and processes. ECP mechanisms of action are still unclear despite evident implication of a complex cascade beginning from the apoptosis of the various cell types collected and exposed to the process that is followed by an immunomodulation via antigen presentation. Exploration of the mechanisms in animal models has many limits that weakness human clinical link. Beside major indications, the barrier to ECP treatment exte.. View More»
  DOI: 10.4172/2157-7633.1000232

  Abstract PDF