Cardiovascular Pharmacology: Open Access

Refaat A Hegazi

Publications

• Mini Review
  The Potential Role of β−Hydroxy−β−Methylbutyrate (HMB) in the Management of Lean Body Mass Loss in Older Adults with Heart Failure and Cardiac Cachexia
  Author(s): Peter A McCullough, Christina B Berberich, Carolyn Alish and Refaat A HegaziPeter A McCullough, Christina B Berberich, Carolyn Alish and Refaat A Hegazi
  
  The loss of muscle mass and strength is a consequence of the aging process and can occur during periods of bed rest, inactivity, trauma, illness as well. For older adults with advanced heart failure (HF)- associated cachexia, disease-related loss of muscle mass and strength is a complication of the disease state and is associated with deconditioning and frailty. As patients with HF progress, the likelihood of developing malnutrition and cachexia increases. Cachexia is associated with lean body mass (LBM) loss and is correlated with a worsening prognosis in HF. Nutrition interventions beyond simple caloric replacement could be an important adjuvant therapy for a better clinical outcome. Specifically, nutrients that improve muscle protein synthesis and decrease degradation are of special consideration for the management of cardiac cachexia. Dietary protein intake, oral nutrition supplem.. View More»
  DOI: 10.4172/2329-6607.1000161

  Abstract PDF