Journal of Pharmacovigilance

Raymond I Ozolua

Publications

• Research Article
  Laboratory-Based Safety Assessment Tests of Some Nigerian Commercial Herbal Products
  Author(s): Raymond I Ozolua and Dickson O UwayaRaymond I Ozolua and Dickson O Uwaya
  
  Introduction: Herbal medicines are becoming increasingly popular for many reasons one of which is the belief in their safety. Nonetheless, prior to their listing/registration, safety evaluation is a requirement by national regulatory agencies and the World Health Organization. Materials and Methods: Four commercial polyherbal products were screened for acute and sub-acute toxicity. Acute toxicity tests involved determination of LD50 and observing rats and mice for gross toxicological symptoms. Groups of rats were administered 2 g/kg/day of the polyherbal products for 28 days at the end of which some hematological and biochemical indices were evaluated. Results: The dose of 8 g/kg of each herbal product did not cause death in the animals suggesting much higher LD50 values. The hematological and biochemical indices were .. View More»
  DOI: 10.4172/2329-6887.S1-001

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