Journal of Microbial & Biochemical Technology

Ramanathan K

Publications

• Research Article
  Extraction of Bioactive Compounds from Millingtonia hortensis for the Treatment of Dapsone Resistance in Leprosy
  Author(s): Anish Kumar, Kshitija Iyer, Shanthi V and Ramanathan KAnish Kumar, Kshitija Iyer, Shanthi V and Ramanathan K
  
  Medicinal plants have been the single most productive source of leads for the development of drugs thus played an important role in treating and preventing a variety of diseases throughout the world. In the present investigation, Millingtonia hortensis was examined for their antibacterial activity particularly against Mycobacterium leprae. Initially, the solvents such as methanol, acetone, benzene and petroleum ether were utilized to extract the chemical components from Millingtonia hortensis. Subsequently, the components were identified by means of GC-MS techniques. Moreover, molecular docking techniques were employed to determine the antibacterial activity of these compounds particularly against Mycobacterium leprae. Finally, Molinspiration and OSIRIS program were utilized to investigate the bioavailability and toxicity of the selected compounds. The results indicates that compounds.. View More»
  DOI: 10.4172/1948-5948.R1-006

  Abstract PDF