Rakesh Das

Publications
  • Short Communication
    Assessment of Endogenous Biochemical Composites Emphasizing Drug Interaction of Cardiovascular Combined Dosage Formulation in Marketed Product
    Author(s): Rakesh Das and Tapan Kumar Pal Rakesh Das and Tapan Kumar Pal

    The study reveals the investigational approaches of a Cardiovascular formulated tablet dosage i.e, Atorvastatin (ATVS) & Olmesartan (OLM) after getting negative feedbacks on pharmaceutical market. A simple, sensitive, precise and rapid analysis under highly sophisticated LCMS/MS system to evaluate the endogenous biochemical composites like Aldosterone (ALD), Angiotensin-II (ANG-II) and Mevalonate (MVA) in plasma concentration level, which associate with mentioned drugs pharmacology. The methods were developed and validated for the same to analyze plasma concentration level among 20 patient volunteers pre-administered with targeted combined tablet dosage. Chromatographic peaks of standard and internal standard exhibits excellent regression curve line and correlative coefficient, r2 =0.998, 0.999 & 0.999 of ALD, ANG-II & .. View More»
    DOI: 10.4172/2329-6887.1000150

    Abstract PDF