Journal of Stem Cell Research & Therapy

Qian Zhang

Publications

• Research Article
  Regulatory Roles of KLF3 in Hematopoiesis of K562 Leukemia Cells
  Author(s): Qian Zhang, Nan Ding, Qian Xiong, Jiawen Zheng, Zexia Li, Yajuan Li, Quanzhen Li, Xiangdong Fang and Zhaojun ZhangQian Zhang, Nan Ding, Qian Xiong, Jiawen Zheng, Zexia Li, Yajuan Li, Quanzhen Li, Xiangdong Fang and Zhaojun Zhang
  
  Objective: KLF3 (Krüppel-like factor 3) is involved in the differentiation and development of a wide range of cell lineages. However, the regulatory roles of KLF3 in hematopoiesis of K562 leukemia cells remain largely unknown. Methods: The public gene expression databases that represent the heterogeneity of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) disease were downloaded from GEO datasets in NCBI. KLF3-deficient K562 stable cells were established and microarray datasets were analyzed. Gene Ontology (GO) analysis was used to identify the affected hematopoiesis-associated genes in KLF3-deficient K562 cells. Ingenuity Pathways Analysis (IPA) was used to identify the affected hematopoiesis-associated functions, interaction networks, pathways and the upstream regulators involving differentially expressed genes (DEGs)... View More»
  DOI: 10.4172/2157-7633.1000310

  Abstract PDF