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Nzelibe HC
Nzelibe HC
Nigeria
Publications
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Research Article
Isolation, Partial Purification and Characterization of L-Asparaginase from Hedgehog Serum
Author(s): Ekpa Emmanuel, Nzelibe HC and Onyike EEkpa Emmanuel, Nzelibe HC and Onyike E
The need to further explore other sources of therapy for leukemias prompted this current work. It’s already known that L-asparaginase possesses a lot of potentials in the treatment of cancers of the white blood cell but the sources of this enzyme and its properties determine the efficacy of this drug. Generally, for asparaginase to be ideally suited for use in anti-tumor therapy, it had to satisfy a variety of criteria. The organism that is selected should produce the asparaginase in high quantity or yield, and it should be capable of being isolated from simple mammalian sources. The procedures developed for purification of the enzyme should be as rapid and simplified as possible. The purified enzyme should have long term stability on storage, maximal activity at a physiological pH, and a Km for substrate below the concentration of the substrate in the blood. Therefore the aim o.. View More»
DOI: 10.4172/1948-5948.1000246